Laurent Duvernay-Tardif studies medicine at McGill University. He suited up for the McGill Redmen of the Quebec University Football League from 2010 to 2013 and won the title of best offensive lineman in Canadian university football in 2013.

He was selected in the 2014 National Football League (NFL) draft in the sixth round (200th overall pick) and has since played with the Kansas City Chiefs.

In May 2018, Laurent Duvernay-Tardif obtained his medical degree and became the fourth player in the history of the National Football League (NFL) to obtain such a diploma.

On February 2, 2020, he participated and won in Super Bowl LIV against the San Francisco 49ers. He is the first Quebecer to win a Super Bowl. On February 18, 2020, he received the Medal of Honor from the National Assembly of Quebec.